Effects of Cordyceps sinensis on macrophage function in high-fat diet fed rats and its anti-proliferative effects on IMR-32 human neuroblastoma cells.

نویسندگان

  • Leandro Freire Dos Santos
  • Rosalia Rubel
  • Sandro Jose Ribeiro Bonatto
  • Adriana Aya Yamaguchi
  • Maria Fernanda Torres
  • Vanete Thomaz Soccol
  • Andre Luís Lopes da Silva
  • Carlos Ricardo Soccol
چکیده

Macrophages have been considered an elusive yet emerging therapeutic target in tumor development since they are an important component in tumor microenvironment. The purpose of the present study was to evaluate the effect of C. sinensis on macrophage function (a component of tumor microenvironment which can alter the virulence of cancer) in high-fat diet fed rats. IMR-32 human neuroblastoma cell cytotoxicity was also investigated. The following parameters were observed to evaluate macrophage function: superoxide anion, hydrogen peroxide, nitric oxide, lysosomal volume and phagocytic capacity. High fat diet (HFD) plus C. sinensis supplementation promoted a decreased superoxide anion and hydrogen peroxide levels as well as lysosomal volume and phagocytic capacity. Nitric oxide was increased in the same group. In summary, C. sinensis offered an important anti-tumoral perspective from the standpoint of the tumor microenvironment and in vitro IMR-32 cytotoxicity.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Protective Effects of Restricted Diet and Antioxidants on Testis Tissue in Rats Fed with High-Fat Diet

Background: A high-fat diet (HFD) and fat accumulation promote the oxidative stress formation, which in turn has hazardous effects on reproductive system and fertility. Therefore, the present study examines the potential positive effects of a restricted high-fat diet (RHFD) and antioxidants consumption on sperm parameters in rats. Methods: 48 male albino wistar rats divided to four groups (n=12...

متن کامل

Effect of troxerutin on apelin-13, apelin receptors (APJ), and ovarian histological changes in the offspring of high-fat diet fed rats

Objective(s): Maternal high-fat diet (HFD) consumption has been linked to metabolic disorders and reproductive dysfunctions in offspring. Troxerutin (TRO) has anti-hyperlipidemic, anti-oxidant, and anti-inflammatory effects. This study examined the effects of TRO on apelin-13, its receptors mRNA and ovarian histological changes in the offspring of HFD fed rats. <...

متن کامل

THE EFFECT OF ALOE VERA HYDROALCOHOLIC EXTRACT ON SPERMATOGENESIS PARAMETERS AND HISTOLOGICAL CHANGES IN THE TESTIS OF RATS FED WITH A HIGH-FAT DIET

Background & Aims: Diseases caused by high-fat diets and obesity are now recognized as a health problem. The aim of this study was to evaluate effect of aloe Vera hydroalcoholic extract on spermatogenesis parameters and tissue structure of testis of rats fed with a high-fat diet. Materials & Methods: 40 adult male Wistar rats were randomly divided into 5 groups (control group (Con), control gr...

متن کامل

اثر نوع تمرین بر نشانگران آپوپتوز هپاتوسیتی در رت‌های تغذیه شده با غذای پرچربب

Background:Anti-inflammation and anti-apoptotic effects of physical activity have been proven and its effectiveness depends on intensity, duration and type. Since obesity is considered as a mild chronic inflammation, it is reasonable that the degenerative damages occurin tissues, especially in the liver as the center of metabolism. The aim of this study was to investigate the effect of two typ...

متن کامل

Anti-oxidant and anti-hyperlipidemic activity of Hemidesmus indicus in rats fed with high-fat diet

Objective: Dietary changes playmajor risk roles in oxidative stress andcardiovascular disease and modulate normal metabolic function. The present study was designed to investigate the ameliorative potential of different extracts of Hemidesmus indicus to experimental high-fat diet in wistar rats, and their possible mechanism of action.  Materials and Methods: Male wistar rats were divided into 6...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Pakistan journal of pharmaceutical sciences

دوره 31 1  شماره 

صفحات  -

تاریخ انتشار 2018